Japanese Center for the Validation of Alternative Methods
Office : New Testing Method Assessment, Division of Pharmacology,
National Biological Safety Research Center (NBSRC),
National Institute of Health Sciences (NIHS)
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JaCVAM Statements
Acute oral systemic toxicity test
- JaCVAMStatement on the cytotoxicity tests to estimate starting doses for acute oral systemic toxicity tests (194 KB)
07_001_02.pdf
- 【NEW】The Regulatory Acceptance Board Report (202 KB)
07_001_04_en.pdf
Skin sensitization test (LLNA-BrdU)
- JaCVAMStatement on the LLNA: BrdU-ELISA for skin sensitization testing (927 KB)
03_002_13.pdf
- 【NEW】The Regulatory Acceptance Board Report (152 KB)
03_002_03_en.pdf
Skin irritation test(EPISKIN)
- JaCVAM Statement on the in vitro tests for skin irritation(250 KB)
04_001_08.pdf - 【NEW】The Regulatory Acceptance Board Report (159 KB)
04_001_04_en.pdf
Isolated Chiken Eye Test
- JaCVAM Statement on in vitro ocular toxicity test methods for identifying ocular corrosive and severe irritants: Isolated Chiken Eye Test Method (472 KB)
05_001_08.pdf
- 【NEW】Peer Review Panel Report (86 KB)
05_001_05_en.pdf
- 【NEW】The Regulatory Acceptance Board Report (133 KB)
05_001_04_en.pdf
Bovine Corneal Opacity and Permeability Test
- JaCVAM Statement on in vitro ocular toxicity test methods for identifying ocular corrosive and severe irritants: Bovine Corneal Opacity and Permeability Test Method (466 KB)
05_002_08.pdf - 【NEW】Peer Review Panel Report (86 KB)
05_002_05_en.pdf
- 【NEW】The Regulatory Acceptance Board Report (135 KB)
05_002_04_en.pdf
Reconstructed human tissue test made in Japan:Vitrolife-Skin
- JaCVAM Statement on the Vitrolife-SkinTM,a3-dimensional cultured skin model for skin corrosivity testing(954KB)
01_001_05_en.pdf - 【NEW】Peer Review Panel Report (140 KB)
01_001_03_en.pdf - 【NEW】The Regulatory Acceptance Board Report (138 KB)
01_001_04_en.pdf
Skin sensitization test (LLNA-DA)
- JaCVAMStatement on the LLNA-DA for skin sensitization testing(506KB)
03_001_01_en.pdf
- 【NEW】The Regulatory Acceptance Board Report (122 KB)
03_001_02_en.pdf
Phototoxicity test
- 【NEW】Peer Review Panel Report (372 KB)
02_002_03_en.pdf - 【NEW】The Regulatory Acceptance Board Report (134 KB)
02_002_02_en.pdf
In Vitro pyrogen test
- 【NEW】The Regulatory Acceptance Board Report (148 KB)
10_001_03_en.pdf
